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At each stenosis, we simulated 4 situations: no catheter/pressure wire insertion (in vivo status), catheter inserted proximally to ICAS without pressure wire, catheter inserted and pressure sensor placed at 1cm&2cm distally to ICAS lesion

Their primary therapeutic actions include stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying to promote satiety, and acting on hypothalamic appetite centers to reduce hunger and caloric intake

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