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Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death
While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig
The detoxification of xenobiotics and excretion of hydrophilic metabolites is brought about by an initial oxidative step that utilises ROS, followed by conjugation of the intermediate metabolite with glucuronic acid, inorganic sulphur, acetyl groups or GSH via GSH transferases (GST) (70, 154)
The model also correctly simulates the metabolic profile of autism when oxidative stress is substantially increased and the adenosine concentration is raised
