Investigator concentration and publication bias
The vast majority of Epithalon research comes from animal studies, cell cultures, and older Russian clinical trials led by Professor Vladimir Khavinson
and the Pharmacy Compounding Advisory Committee subsequently voted against adding it to the Category 1/503A bulk drug substances list at its late-2024 meetings, leaving it without a confirmed legal compounding pathway at that time
It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo
The synthesis and metabolism of thyroid hormones depend on selenium
As a result, the body lacks the materials needed to produce new glutathione