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[PubMed: 1569148] 96

Since AOMs are indicated in combination with lifestyle interventions, all participants received dietary and physical activity counseling, aiming to achieve a 500-kcal deficit per day and 150 minutes of physical activity per week

The precise timing depends on the route of administration: intravenous delivery typically produces measurable effects within 5-15 minutes, whilst subcutaneous or intramuscular administration may require 15-30 minutes for peak responses

musculoskeletal symptoms, such as muscle soreness and weakness and joint pain

doi:10.3390/nu13061913

10.3324/haematol.2018.190876 Haematologica 57 InamotoY.KimuraF.KandaJ.SugitaJ.IkegameK.NakasoneH.et al (2016)