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To increase the predictive accuracy of the candidate marker panel, we constructed a multivariate orthogonal partial least squares-discriminant analysis (OPLS-DA) model using the seven significant metabolites identified by GLM

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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

J Psychosom Res (2002) 53(4):86571