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Studies have shown that certain polyphenols such as oleuropein (from olive leaf/olive oil) or curcumin (turmeric) reduce NF-B and activate antioxidant enzyme pathways (Nrf2)

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We can see these shifts in fuel utilization by using metabolic chambers to determine substrate utilization by analyzing the respiratory exchange ratio (RER), which is derived from oxygen consumption and carbon dioxide production

Ultrathin sections (80 nm thick) were cut with an ultramicrotome (Leica, EMUC6, Germany), and then stained with uranyl acetate and lead citrate and finally examined by a Tecnai G 2 Spirit TWIN transmission electron microscope (FEI, Hillsboro, OR, USA)