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Nutrition Research Other Articles Choline What it does General Humans can synthesize small amounts of choline but not enough to support health

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Dysregulated BCL-2 expression contributes to leukemic cell survival and accumulation, while the MCL-1 protein exerts a protective effect on CLL cells, inhibiting apoptosis (15, 16)

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Opportunities and challenges in targeting TDLNs LN-targeted immunotherapy As TDLNs are widely recognized for playing a key role in driving the immunotherapy response, it is hypothesized that the effectiveness of ICB relies predominantly on an influx of newly primed T cells into the tumor from peripheral lymphoid organs, particularly the TDLNs, rather than on reinvigorating exhausted and fully differentiated T cells that already exist in tumors (233)

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