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Additionally, in vitro models require smaller sample sizes and offer higher throughput at a more affordable cost ( The liver plays a central role in the homeostasis of the whole organism as well as plays a key role in drug metabolism and biotransformation, with many active metabolic processes susceptible to being altered after exposure to drugs

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2013;319(3):1222 (Epub 2012/11/17)

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[DOI] [PubMed] [Google Scholar] 30.Jaume JC, Guo J, Pauls DL, et al