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Archives of Virology, Volume 170, article number 1

In PD models, markers of ferroptosis include decreased GPX4 activity, GSH depletion, and elevated lipid peroxides [208]

Kasperczyk S, Dobrakowski M, Kasperczyk A, Machnik G, Birkner E (2014a) Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers

doi: 10.2174/0929867327666200705225821, 164 PourayyoubiB.Rezaei-AshtianiA.JavaheriJ.Ebrahimi MonfaredM.ZamaniF

Anti-Aging Benefits: As an antioxidant, glutathione helps protect cells from damage, which can slow down the aging process and reduce the appearance of aging-related signs like wrinkles and fine lines

In another study they described a similar GSH reduction in red blood cells of sALS patients treated with insulin-like growth factor 1 (IGF-1), but probably only as a secondary cytotoxic effect due to the treatment with IGF-1 [103]