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These DNA lesions result in cell cycle arrest, apoptosis or necrosis, directly impacting tumor cell survival (2)

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Freely diffusing NADH in aqueous solution, when excited at the nicotinamide absorbance of ~335 nm (near-UV), fluoresces at 445460 nm (violet to blue) with a fluorescence lifetime of 0.4 nanoseconds, while NAD + does not fluoresce

These include inhibitors of JAK, dimerization suppressors, phosphopeptides targeting the SH2 domain of STAT-6, decoy oligonucleotides, siRNAs, and finally synthetic small molecules

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