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The gut microbiota regulates the metabolism and side effects of irinotecan (CPT-11), a topoisomerase inhibitor prodrug of SN-38 that is frequently used to treat colorectal cancer (Wallace et al., 2018)

Immunometabolic control of trained immunity

It is renowned for its role in promoting lipolysis, the process of breaking down fats, by selectively targeting adipose tissue

However, continuous use should ideally be discussed with a healthcare provider, especially if you have underlying health conditions or are taking other medications, to ensure it remains appropriate for your individual needs and to monitor for any potential interactions or prolonged effects

Human studies on DSIP remain limited, and more research is needed to fully understand how effective it is long term