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EMT, a pivotal mechanism in fibrogenesis, involves the phenotypic transformation of polarized epithelial cells into motile mesenchymal cells, marked by loss of apical-basal polarity, dissolution of intercellular adhesions, and acquisition of migratory and invasive properties

Furthermore, CHAC2 was upregulated in a model of APAP-induced hepatic damage following treatment with naringin (Zhai et al., 2022)

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When free intracellular ferrous ions accumulate in the cytoplasm, ROS are generated via the Fenton reaction, subsequently leading to ferroptosis in tumor cells

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