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It affects metabolism, oxidation, and aging via sirtuin pathway activation

Reduction in the activity of genes such as the one that regulates the enzyme methyl-enetetrahydrofolate reductase (MTHFR) increases mean homocysteine levels

Moreover, mitochondrial dysfunction activates inflammatory pathways, producing pro-inflammatory cytokines and chemokines (de Mello et al., 2018)

Abstract Background Individuals with vitamin B12 deficiency (including pernicious anaemia) often report being let down or stigmatised by general practice systems and policy, and choose instead to self-medicate via injection

The reduction of these disulfide bonds results in oxidation of thioredoxin which then is reduced by thioredoxin reductase