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Most side effects are temporary and mild, but some rarer complications can occur

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Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, et al

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Energy metabolism B12 is an essential cofactor in the conversion of food into usable cellular energy

4.1.5 Limitations in clinical evidence and translational relevance Current clinical research on natural products is marred by methodological deficiencies, including small cohorts, inadequate controls, and non-standardized endpoints