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Patients receiving B12 for a diagnosed deficiency may begin with more frequent injections before moving to a maintenance schedule

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For example, one early protocol for substance uses disorders employed 500-1,000 mg of NAD+ per day delivered by slow intravenous infusion over several consecutive days

In further support of the important role of L-glutamate metabolism in meningococcal virulence, gdhA was found to be essential for meningococcal survival in the infant rat model (Sun et al., 2000)