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Animal studies have generally reported no significant treatment-related adverse effects

(2017) showed that 8 g of CM 1-h before exercise failed to improve mean power output or fatigue index during a cycling Wingate, within a group of 17 trained tennis players

In mammals, HRD1 mediates K48-linked degradation of BMAL1, regulating transcriptional activity of downstream circadian genes ( Other polyubiquitin linkages, like K29 and K11, may modulate clock function without directly inducing degradation or indirectly via influencing pathways involved

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doi: 10.2165/00003495-200161150-00002

White C, Ji S, Cai H, et al (2012) Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders