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Its ability to activate sirtuins, enhance DNA repair, regulate metabolism, influence fat cell metabolism in preclinical models and support mitochondrial health positions it as a compelling candidate for further investigation

Nat Genet (2011) 43(10):9329

Available animal data and in vitro observations suggest a relatively short plasma halflife typical of small peptides (minutes to a few hours) when measured in circulation

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This would result if the bioavailable pool of a particular metal is insufficient to metalate all cognate metalloproteome sites quantitatively, and is of course a prediction of the set-point metallostasis model, where the free energy of (mis)metalation is positive (+ G ) (Figure 8B)