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Further exploration of the pathways through which ROS influences mitophagy to alter the progression of ischemic cardiomyopathy has shown that inhibition of Parkin-mediated mitophagy leads to excessive mitochondrial ROS accumulation, promoting myocardial injury and heart failure [85]

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Mechanism of Action (How DSIP Works) CNS Penetration: Crosses the blood-brain barrier, exerting central effects on sleep regulation [Graf 1981]

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