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Accordingly, several in vitro , pre-clinical and clinical studies have reported low immunogenicity, anti-inflammatory, anti-bacterial, anti-oxidative, and anti-scarring properties of placental-derived materials in different skin wound healing models, and 28 decellularized or devitalized placental matrices are currently FDA approved for clinical use as wound dressings (Kim et al., 2015

However, challenges persist in developing efficient approaches to controllably integrate antioxidant nanocatalysts with TRAF6 inhibitors into a single platform, as well as in achieving effective and targeted delivery of both agents to lesional macrophages to maximize their therapeutic potentials

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doi: 10.1016/j.yrtph.2017.09.014

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