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Antioxidant strategiessuch as Nacetylcysteine (NAC), glutathione enhancers, or combinations of vitamins E and Chave demonstrated the ability to suppress ROSdriven NET formation in vitro, lowering NETosis markers while preserving basal neutrophil function [102]

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In lung adenocarcinoma (LUAD) cells, the E3 ligase MIB1 was shown to induce ubiquitination of Nrf2 in the Neh2 structural domain, following which the ubiquitinated Nrf2 was degraded via the proteasomal pathway

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