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On the other hand, IRPs combine with the IRE on the transferrin receptor mRNA to stabilize its mRNA, promote the expression of transferrin receptor, and increase iron uptake (Recalcati et al., 2010

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Yet, it has been shown that the import and folding of many cysteine-containing IMS proteins rely on the introduction of intramolecular disulfide bonds in the IMS, a process that is facilitated by the IMS-resident oxidoreductase Mia40 [66,171,172]

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It is made by the liver and is important for many body functions

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