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J Clin Invest (2016) 126(5):16309

Methods: Patients with untreated bAVMs, categorized into seizure and non-seizure groups were recruited for this study

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Even if clinical trials suggest tolerability, the real-world risk profile changes when: the source and purity of the peptide are uncertain, its used in different routes than studied, its used in stacked protocols with other drugs, its used in populations the trials didnt represent