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However, native GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) and cleared renally, giving it a plasma half-life of only 12 minutes far too short for practical research or clinical application

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This solution was sterile filtered through a 0.2 filter and slowly added to a stirred diethylether (50 ml)

By inflating the balloon, the electrodes are brought into contact with the mucosa, and impedance is registered for 90 s as a read-out for mucosal integrity (56, 57)

Topical absorption is significantly lower than injection