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PD The degeneration of dopaminergic neurons in PD is fueled by iron overload, mitochondrial dysfunction and oxidative stress, all of which are tightly linked to ferroptosis
Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90
demonstrated significant downregulation of miR-221 in colorectal cancer (Caco-2 cells), leading to upregulation of TP53INP1 ( p C), significantly affect pump activity, with TT genotypes showing higher extrusion capacity
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By integrating both mechanistic and clinical evidence, this review aims to improve understanding of curcumins potential role and inform its future application in the management of DACD
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