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200 mg) produce evidence for beta-1 stimulation in patients (rxlist.com) This mechanism is associated with cardiovascular adverse effects, including clinically significant increases in blood pressure, tachycardia, and hypertension (Segovia & Crisp 2021)

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Cholesin interacts with G protein-coupled receptor 146 (GPCR146), inhibiting the PKA-ERK1/2-SREBP- 2 signaling pathway and suppressing hepatic cholesterol synthesis

Remember that supplements complement, but don't replace, fundamental health practices like maintaining healthy weight, limiting alcohol intake, eating a nutrient-dense diet, and managing metabolic health