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Both autopsy studies and clinical trials have found that 15% to 30% of individuals who meet the criteria for clinical Alzheimer's dementia based on symptoms did not have biomarkers of Alzheimer's disease, that is, they did not have a biological diagnosis of Alzheimer's disease

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A protocol designed around smaller, more frequent measurements typically calls for a different concentration than one built around larger, less frequent draws and since concentration is simply peptide mass divided by liquid volume, changing either side of that relationship changes the correct water volume

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Additionally, exogenous BDNF has a protective effect against ethanol-induced damage in primary culture neurons from rat hippocampi (66)

Knockin on heavens door: Molecular mechanisms of neuronal tau uptake