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In 1973, Loren Pickart and Margaret Thaler reported that a small factor in human serum could prolong the survival of normal liver cells and modulate growth in liver tissue, and that plasma from younger donors was more active than plasma from older donors

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Nixon B, Bielanowicz A, Anderson AL et al (2010) Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa