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Description

Lifespan changes have been reported in flies and selected mouse models

M., Hollinger M

Data are shown as the mean SD

Outside of the R-domain, both structures match closely with a C RMSD of 2.3 and similar overall topology

This disrupts the balance of mitochondrial regulation mechanisms due to their strong connection with the guts microbial community ( SLC25A28 (mitoferrin 2), VARS (valine-tRNA ligase), and RNF5 (E3 ubiquitin ligase)

In other cases, the regulatory Zn II coordination site may be at or very near the protein surface where it functions at a distance as an allosteric modulator of protein function