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mTORC1 promotes the expression of lactate dehydrogenase A (LDHA) and Pyruvate kinase isozyme type M2 (PKM2) by activating HIF-1 and catalyzes the reductive carboxylation of glutamine to generate lipid precursors, thereby aggravating synovial inflammation (78, 79)

The effects of melittin and apamin on airborne fungi-induced chemical mediator and extracellular matrix production from nasal polyp fibroblasts