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PMID: 88 MaoXMaJJiaoCTangNZhaoXWangDet al

Ion pumps and exchangers are unable to keep up with the increasing concentrations of Ca 2+ , which is not pumped out of the cell, and high Ca 2+ levels trigger the release of glutamate, a major contributor to ischemia-induced excitotoxicity in neurons and glial cells (Papazian et al., 2018

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-B

While animal models have shown a favorable safety profile, and many individuals report positive experiences, the absence of extensive human clinical trials means that caution is advised

In certain embodiments, such measurements may utilize, for example, the Tietze method (Tietze, F