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Consisting of three distinct isoforms, LH1 primarily hydroxylates lysine along the helical domain of the -chains to form Hyl (Gjaltema and Bank, 2017)

Prior history of ulcer or other gastrointestinal complications increase risk of NSAID ulcers 4- to 5-fold

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Recent studies also suggest that it might be able to raise lowered plasma levels of glutathione

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One approach is to select these active molecules as lead compounds for new drug development, using medicinal chemistry to optimize their efficacy and pharmacokinetic properties