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Consequently, older adults are more likely to have sub-optimal B12 levels even when dietary intake is adequate

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Francisco Triana-Martnez et al., in their research, administered gemcitabine alone (25 mg/kg, IP), digoxin alone (2 mg/kg, IP), or a combination of both drugs at the same doses through intraperitoneal injections to immunocompromised mice that had previously been subcutaneously injected with A549 lung adenocarcinoma cells [140]

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El-Beshbishy, H

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Human evidence: Moderate, based on Khavinson's geriatric clinical observations

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Table 1 Therapeutic strategies targeting hypoxia and metabolic reprogramming in cancer

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