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Furthermore, activated AMPK exerts hepatoprotective effects through metabolic and anti-inflammatory mechanisms: it inhibits mTORC1 and SREBP-1c to reduce lipid synthesis, while suppressing NF-B signaling and oxidative stress via the sirtuin 1/FOXO1 pathway (Wu et al., 2025)

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Recurrent parathyroid carcinoma and the need for molecular profiling to aid in prognostication and therapeutics

It also appears in peripheral organs and body fluids, suggesting systemic regulatory functions beyond the central nervous system

[DOI] [Google Scholar] 273.Delledonne M., Xia Y., Dixon R.A., Lamb C

Even though O 2 is the leading ROS in the mitochondria, it is converted to H 2 O 2 by the Mn-SOD and the APX (Sharma et al., 2012)