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The TrxR3 enzyme is encoded by the TXNRD3 gene located on chromosome 3q21.3 and is composed of 16 exons that generate two alternatively spliced mRNAs resulting in two different isoforms of TrxR3

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Obsessive-compulsive disorder (OCD): An RCT in 48 patients found that NAC (2,400 mg/day) as an add-on to fluvoxamine significantly improved Yale-Brown OCD Scale scores compared to placebo over 12 weeks (Afshar et al., J Clin Psychopharmacol, 2012) [72]