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Furthermore, the colocalization of vacuoles with mitochondria and Mcp1-GFP localization under non-fermentable carbon source (YPG) conditions were investigated

Chen X, Yu C, Kang R, Tang D

Upregulation of COL1A1 and FN1 genes in OA FLS and elevated levels of pro-inflammatory markers such as PGE2 , IL6 , and IL8 in mechanically loaded samples demonstrate the interchangeable influences of mechanical forces and TGF- signaling (154, 155)

52 FongJ.YuanM.JakobsenT

Future studies will need to examine long-term safety, effects in female mice, tissue-specific responses, optimal dosing, and possible off-target effects