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Retatrutide achieved 24.2% weight loss in Phase 2 trials

By blocking NNMT, 5-amino-1MQ promotes an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor essential for cellular metabolism

This action protects the cell from programmed death, simultaneously safeguarding senescent cells from apoptosis [111]

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In some embodiments, the otoprotectant is a compound of Formula (VI) having the structure of Formula (VIa): In some embodiments, the otoprotectant is a compound of Formula (VII): wherein: X is a single bond, double bond, CH 2 , or O

MSCs were seeded in a 24-well plate with 35 10 3 cells/well density after the second passage