Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]
Glutathione mutants showed also a higher susceptibility to SFN treatment To address the question if the more susceptible phenotype of glutathione mutants towards AITC was unique for this GHP, sulforaphane (SFN), an aliphatic ITC possessing a longer side chain than AITC, was tested
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Oncotarget 7:3868138692 Almilaji A, Pakladok T, Guo A, Munoz C, Foller M, Lang F (2012) Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR
P = .006) and rs301435 (2 = 9.24
