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The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)

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Mazokopakis EE, Kotsiris DA (2014) Hashimoto's autoimmune thyroiditis and vitamin D deficiency

Chronic scalp inflammation damages follicles over time, contributing to miniaturization and eventual hair loss

doi: 10.35975/apic.v26i5.1993 204 Jarmakiewicz-CzajaSFerencKFilipR

248,265 TGF- can activate the expression of EMT-related transcription factors through the TGF-/Smad signaling pathway, which in turn promotes cell invasion and metastasis