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Although the interaction between endothelial dysfunction and vascular complications of diabetes is not fully understood, the existing view shows that a high glucose environment leads to the impairment of endothelium-dependent vasodilation capacity by increasing oxidative stress and inflammation, reducing vasodilation factor activity, increasing reactive oxygen species (ROS) production, promoting the uncoupling of endothelial nitric oxide synthase (eNOS), and so on ( Figure 2 )

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10.3390/nu16091273 89 MurakamiT.BodorE.BodorN

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The science is biologically plausible, the early findings are encouraging, and the available safety data appears favorable, but its important to be transparent about what we know, what we dont know, and where the evidence still needs to mature

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Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK. FEBS Letters , 238(2), 343346

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