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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

Results from a 2017 study show an association with consuming high-dose B6 and B12 vitamin supplements over 10 years with an increase in lung cancer risk in men, especially smokers (Brasky, 2017)

Theoretical considerations regarding cell proliferation effects should be considered

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