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Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route

The standard approach is to take your last dose of the old medication on its normal schedule and start the new medication on what would have been your next scheduled injection day

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When NNMT activity is reduced, less nicotinamide is methylated and wasted, allowing NAD pools to remain higher