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doi:10.3390/jox15010001 Moustakli E, Potiris A, Grigoriadis T, et al

& Romano, R

Targeting glutaminase and transaminase as a treatment for cancer GLS, which is highly expressed in cancer cells and plays a role in cancer progression, has been investigated extensively as a druggable target 41

Elevated levels of cytokines, such as TNF- and IL-6, disrupt the testicular microenvironment, affecting nutrient supply and metabolic balance essential for sperm production [67]

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Nevertheless, DFOs clinical applicability is constrained by poor BBB penetration and non-oral administration route, prompting the development of modified delivery systems(e.g., DFO-gold nanoparticle conjugates, NCT05022472) currently under preclinical optimization