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Statements Author contributions MoA: Investigation, Validation, Visualization, Writing original draft, Writing review and editing
BPC-157 is generally well-tolerated when used as directed, and severe side effects are rare
At the molecular signaling level, the combination produces simultaneous activation of pathways that are normally activated in sequence during natural wound healing
Thereby, the application of NO-agents, NOS-blockade L-NAME, NO-over-activity (L-arginine, NOS-substrate) and their relationships (opposite or parallel activities, mutual counteraction or not), which can cover all essential points of NO-system, and the full spectrum of NO-system functions was combined with BPC 157 application to show its full efficacy on maintaining and/or reestablishing NO-system effects and functions [124,125]
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