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Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis

There can be tolerance with repeated use, which degrades efficacy and increases doses, leading to safety concerns

GSH-mediated protection has been observed when used with quinolones and aminoglycosides, such as ciprofloxacin, norfloxacin and spectinomycin (Goswami et al., 2006

Participants experienced up to a 20% increase in blood levels of the antioxidant enzyme superoxide dismutase, and up to a 29% increase in vitamin C levels

10.1155/2014/648308 86 JiangM.LiC.LiuQ.WangA.LeiM