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(PubMed) Yamamoto H, Watanabe T, Mizuno H, et al

It seems that STAT3 signaling possesses the properties which might reprogram the phenotypes of both immune and non-immune cells to enhance the aging process and thus this phenomenon may be an important contributor to age-related diseases

Animal models offer a platform to mitigate the effects of donor variations, such as age, ethnicity, sex, genetics, and habits (such as smoking), which directly impact the characteristics of stored erythrocytes [7-9]