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The Potential M PRO Targets TXNRD1 and GCLC are Strongly Upregulated by Vitamin D3 In light of accruing evidence that vitamin D3 status is inversely correlated with severity of COVID-19 (2326), it is significant that, via its hormone-like actions on gene expression, D3 has been shown to be a potent activator of both TXNRD1 and GCLC