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Treatment intolerance: Presence of adverse effects preventing the continuation or escalation to an adequate therapeutic dose of the immunosuppressive drug

Plant Physiol 135(3):16301641

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But, interestingly, studies don't always back it up

Propylene glycol

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome