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As also observed for FOXO4 FH binding, the R 1 relaxation rates of p53 194 remained unaltered in presence of FOXO4-DRI (Supplementary Fig

Standard TB-500 protocol: Loading phase (Weeks 1-4): 5mg twice weekly (Monday/Thursday) Total per week: 10mg Total for loading: 40mg (8 vials of 5mg) Maintenance phase (Weeks 5-12): 2-5mg once weekly Total per week: 2-5mg Total for maintenance: 16-40mg (3-8 vials) Example: 5mg vial + 2ml water = 2,500mcg/ml 5mg dose (5,000mcg) = draw 2.0ml (full vial) 2.5mg dose = draw 1.0ml TB-500 doses are MUCH larger than BPC-157