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US Patent US20230331803A1 (2023)

Brain Behav Immun 93:312321

A mild concussion with intact blood-brain barrier presents a very different repair challenge than a severe TBI with diffuse axonal injury and widespread inflammation

By co-dispensing these pharmacophores in a single 30 mL hydrogel, clinicians may reduce polypharmacy burden, enhance adherence, and address erythematous, inflammatory, and sensitivity dimensions of rosacea in one vehicle

It has been extensively studied in animal models for its regenerative effects across multiple tissue types, including tendon, ligament, vascular endothelium, muscle, and intestinal mucosa

For example, the inhibition of cell proliferation by curcumin has been associated with the Nrf2-dependent downregulation of DNA repair-specific flap endonuclease 1 (Fen1) in breast cancer cells in culture (46)