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Sequencing was carried out by Sanger methodology on ABI PRISM 310 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA) and 100% concordance with restriction fragment length polymorphism assays was shown providing confidence in using the full dataset in subsequent analysis

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Several cell death pathways, including apoptosis [3], necrosis [4], and autophagy [5] have been described in AD brain [6,7,8]

Regression coefficients were calculated for the proportion of normal oocytes for each group divided by the number of diagnosed oocytes